Table 1. Brain and plasma levels of monoamines and their metabolites.
Striatum | Hippocampus | Prefrontal cortex | Plasma | ||
---|---|---|---|---|---|
Control | 51.13±1.10 | 32.14±1.67 | 23.81±0.69 | 160.45±3.70 | |
DA | LPS | 80.61±2.79 | 38.52±1.00 | 33.26±1.33 | 213.55±4.51 |
T-test | t(41) = -10.65, p<0.001 | t(41) = -3.07, p<0.01 | t(41) = -6.68, p<0.001 | t(41) = -9.19, p<0.001 | |
Control | 15.43±0.50 | 24.91±0.52 | 16.03±0.46 | 7.42±0.19 | |
DOPAC | LPS | 25.40±1.08 | 29.30±0.77 | 22.55±0.78 | 8.95±0.13 |
T-test | t(41) = -8.97, p<0.001 | t(41) = -4.91, p<0.001 | t(41) = -7.52, p<0.001 | t(41) = -6.39, p<0.001 | |
Control | 7.45±0.27 | 16.81±0.53 | 14.84±0.69 | 4.94±0.18 | |
3-MT | LPS | 4.53±0.17 | 14.02±0.38 | 9.28±0.60 | 7.90±0.30 |
T-test | t(41) = 8.62, p<0.001 | t(41) = 4.07, p<0.001 | t(41) = 5.91, p<0.001 | t(41) = -8.74, p<0.001 | |
Control | 12.76±0.38 | 27.79±1.26 | 18.77±0.66 | 5.69±0.28 | |
HVA | LPS | 21.70±0.69 | 38.35±1.94 | 25.73±0.70 | 9.23±0.24 |
T-test | t(41) = -11.88, p<0.001 | t(41) = -4.73, p<0.001 | t(41) = -7.19, p<0.001 | t(41) = -9.36, p<0.001 | |
Control | 24.80±0.77 | 33.47±1.50 | 25.30±0.60 | 46.33±2.04 | |
5-HT | LPS | 18.62±1.12 | 22.54±0.90 | 19.53±0.59 | 41.89±1.79 |
T-test | t(41) = 4.68, p<0.001 | t(41) = 5.84, p<0.001 | t(41) = 6.75, p<0.001 | t(41) = 1.59, p = 0.12 | |
Control | 13.59±0.69 | 17.51±0.48 | 22.67±1.00 | 230.50±3.53 | |
5-HIAA | LPS | 20.00±0.85 | 22.96±1.57 | 30.29±0.98 | 245.32±2.35 |
T-test | t(41) = -5.91, p<0.001 | t(41) = -3.64, p<0.001 | t(41) = -5.36, p<0.001 | t(41) = -3.30, p<0.01 |
Values (ng/ml) represent mean ± SEM.