Table 3. Brain and plasma levels of tryptophan and kynurenine pathway metabolites.

		Striatum	Hippocampus	Prefrontal cortex	Plasma
	Control	6.63±0.26	6.25±0.27	5.95±0.27	4.09±0.11
TRP	LPS	20.17±1.08	20.46±1.70	21.57±1.57	6.67±0.24
	T-test	t(41) = -13.48, p<0.001	t(41) = -9.25, p<0.001	t(41) = -10.98, p<0.001	t(41) = -10.34, p<0.001
	Control	63.93±1.00	75.59±1.66	66.99±0.89	65.13±1.40
KYN	LPS	111.83±1.89	107.46±2.86	109.86±1.48	94.58±1.83
	T-test	t(41) = -23.76, p<0.001	t(41) = -10.10, p<0.001	t(41) = -25.94, p<0.001	t(41) = -12.99, p<0.001
	Control	23.15±2.13	23.18±2.11	23.23±2.08	1.89±0.08
KYNA	LPS	23.89±2.95	23.01±3.15	22.23±3.08	1.80±0.10
	T-test	t(41) = -0.20, p = 0.84	t(41) = 0.05, p = 0.96	t(41) = 0.28, p = 0.78	t(41) = 0.71, p = 0.48
	Control	17.81±0.74	21.18±0.71	19.30±0.60	47.88±0.72
3-OH-KYN	LPS	36.20±1.15	40.48±0.75	37.10±1.26	75.21±2.03
	T-test	t(41) = -13.96, p<0.001	t(41) = -18.50, p<0.001	t(41) = -13.59, p<0.001	t(41) = -13.84, p<0.001
	Control	32.84±0.72	32.33±0.52	32.35±0.61	16.65±0.43
QUIN	LPS	43.41±0.46	41.05±0.78	40.43±0.96	22.24±0.46
	T-test	t(41) = -11.88, p<0.001	t(41) = -9.38, p<0.001	t(41) = -7.33, p<0.001	t(41) = -8.83, p<0.001

Values (ng/ml) represent mean ± SEM.