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. 2015 Jan 20;10(1):e0117011. doi: 10.1371/journal.pone.0117011

Table 2. Most significant SNP-by-maternal treatment interactions.

SNP Transcript
SNP ID 1 rs number Chr Position 2 Accession Gene 3 Chr P-value 4
kgp11796917 rs146836802 14 30685942 NM_194323 OTOF 2 1.09x10–57
kgp30566776 rs73229805 X 67014865 NM_001010927 TIAM2 6 3.53x10–45
kgp8430951 rs78240927 6 163766098 NM_001100422 SPATS2L 2 2.37x10–37
kgp11155608 rs12059564 1 159000779 NM_015913 TXNDC12 1 7.81x10–32
kgp1360358 rs35447805 8 85131756 NM_080415 SEPT4 17 4.70x10–30
kgp6389054 rs78957751 16 34886264 NM_001006630 CHRM2 7 4.14x10–27
rs4764191 rs4764191 12 15560196 NM_001032295 SERPING1 11 4.43x10–27
kgp11709552 rs62227091 22 47811418 NM_001011724 HNRNPA1L2 13 3.15x10–26
kgp30620929 rs140547157 X 27936207 XM_945614 PMS2L1 7 3.32x10–26
kgp11042611 rs79592528 3 122772698 XM_938400 LOC142937 10 3.97x10–26
kgp8787288 rs940676 2 121235234 NM_003733 OASL 12 8.00x10–25
kgp4545030 rs78211484 12 59934484 CK299576 HS.528210 3 5.46x10–24
kgp18518 rs17757256 2 19650629 NM_001007524 F8A3 X 1.19x10–23
kgp2333358 rs1461092 12 41556961 NM_005419 STAT2 12 4.89x10–23
kgp8581526 rs36117773 5 11939359 NM_025126 RNF34 12 1.15x10–22
kgp494941 rs79270474 12 12338554 NM_002535 OAS2 12 1.59x10–22
kgp6448962 rs57573303 9 28322259 NM_001012978 BEX5 X 5.84x10–22
rs3803712 rs3803712 16 26074500 NM_001712 CEACAM1 19 7.21x10–22
kgp36317 rs2247335 6 106992592 NM_001007234 ERCC8 5 8.83x10–22
kgp4630305 rs59557850 8 78148122 NM_003728 UNC5C 4 1.10x10–21
rs9655226 rs9655226 7 22598742 NM_170695 TGIF1 18 3.07x10–21
kgp10592712 rs73063011 19 52338183 NM_024032 C17ORF53 17 8.71x10–21
kgp237322 rs539822 5 176310164 XM_001721497 LOC100132457 2 1.02x10–20
rs11053624 rs11053624 12 10283711 NM_015589 SAMD4A 14 1.51x10–20
kgp11540460 rs144298037 6 45434746 NM_001004349 FLJ45422 6 1.56x10–20
kgp11526978 rs4711691 6 12404895 NM_014453 CHMP2A 19 3.55x10–20
kgp11514400 rs35833993 6 165457847 NM_006918 SC5D 11 5.65x10–20
kgp3001132 rs9606166 22 19811720 NM_006704 SUGT1 13 6.90x10–20
kgp9305036 rs943009 6 11243891 NR_002940 LRRC37A4 17 1.59x10–19
kgp8789955 rs62576233 9 84337468 NM_005792 MPHOSPH6 16 1.63x10–19
kgp1173427 rs61733660 6 151148947 XM_925998 SRA1 5 1.82x10–19
rs2968402 5 rs2968402 4 16 21947480 NM_014598 SOCS7 17 3.16x10–19
kgp12304307 rs13298711 9 83820909 NM_002256 KISS1 1 3.45x10–19
rs11636802 rs11636802 15 56775597 DA276856 HS.576243 1 3.53x10–19
kgp12481432 rs4407201 2 130522894 NM_016134 CPQ 8 4.88x10–19
kgp31122632 rs138131809 X 116143012 NR_024524 LOC100129055 10 6.25x10–19
rs7149078 rs7149078 14 32844576 CD369504 HS.540642 16 6.57x10–19
kgp4554682 rs1108962 4 100663492 AI274046 HS.555512 14 8.86x10–19
kgp8947215 rs73030956 12 1675847 NM_018271 FLJ10916 2 9.40x10–19
kgp7059559 rs1831464 13 92902619 NM_019062 RNF186 1 9.67x10–19
kgp4609959 rs13284671 9 824742 NM_002720 PPP4C 16 1.02x10–18
kgp2913569 rs36067040 1 224238495 NM_001017977 DCAF6 1 1.32x10–18
kgp1360358 rs35447805 8 85131756 NM_005533 IFI35 17 1.67x10–18
kgp6643156 rs79321471 14 101498881 NM_017831 RNF125 18 1.81x10–18
kgp619464 rs4292995 1 30738298 NM_022148 CRLF2 Y 2.36x10–18
rs6074541 rs6074541 20 12978517 NM_006286 TFDP2 3 2.87x10–18
kgp12299095 rs35007051 2 188415764 NM_002164 IDO1 8 3.76x10–18
kgp12307971 rs76107005 10 85534815 NM_002201 ISG20 15 4.36x10–18
kgp10871570 rs115462216 21 22882926 U43604 HS.550193 5 4.78x10–18
rs3025651 rs3025651 6 29539914 NM_003646 DGKZ 11 6.03x10–18

List of the top 50 significant interactions. Regulated transcripts and respective p-values are shown.

SNP with the most significant association obtained from comparison of all BMS (N = 22) and AMS (N = 23) offspring was shown for each transcript.

1 SNP ID as defined by Illumina HumanOmni-5-Quad BeadChip annotation.

2 Genome build 37.

3 RefSeq or UniGene nomenclature.

4 P-values for differences between regression slopes (BMS vs. AMS) obtained from an additive model.

5 SNP mapped at two locations (chr16:21947480 and chr16:29119905). Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome.