Table 2. Most significant SNP-by-maternal treatment interactions.
SNP | Transcript | ||||||
---|---|---|---|---|---|---|---|
SNP ID 1 | rs number | Chr | Position 2 | Accession | Gene 3 | Chr | P-value 4 |
kgp11796917 | rs146836802 | 14 | 30685942 | NM_194323 | OTOF | 2 | 1.09x10–57 |
kgp30566776 | rs73229805 | X | 67014865 | NM_001010927 | TIAM2 | 6 | 3.53x10–45 |
kgp8430951 | rs78240927 | 6 | 163766098 | NM_001100422 | SPATS2L | 2 | 2.37x10–37 |
kgp11155608 | rs12059564 | 1 | 159000779 | NM_015913 | TXNDC12 | 1 | 7.81x10–32 |
kgp1360358 | rs35447805 | 8 | 85131756 | NM_080415 | SEPT4 | 17 | 4.70x10–30 |
kgp6389054 | rs78957751 | 16 | 34886264 | NM_001006630 | CHRM2 | 7 | 4.14x10–27 |
rs4764191 | rs4764191 | 12 | 15560196 | NM_001032295 | SERPING1 | 11 | 4.43x10–27 |
kgp11709552 | rs62227091 | 22 | 47811418 | NM_001011724 | HNRNPA1L2 | 13 | 3.15x10–26 |
kgp30620929 | rs140547157 | X | 27936207 | XM_945614 | PMS2L1 | 7 | 3.32x10–26 |
kgp11042611 | rs79592528 | 3 | 122772698 | XM_938400 | LOC142937 | 10 | 3.97x10–26 |
kgp8787288 | rs940676 | 2 | 121235234 | NM_003733 | OASL | 12 | 8.00x10–25 |
kgp4545030 | rs78211484 | 12 | 59934484 | CK299576 | HS.528210 | 3 | 5.46x10–24 |
kgp18518 | rs17757256 | 2 | 19650629 | NM_001007524 | F8A3 | X | 1.19x10–23 |
kgp2333358 | rs1461092 | 12 | 41556961 | NM_005419 | STAT2 | 12 | 4.89x10–23 |
kgp8581526 | rs36117773 | 5 | 11939359 | NM_025126 | RNF34 | 12 | 1.15x10–22 |
kgp494941 | rs79270474 | 12 | 12338554 | NM_002535 | OAS2 | 12 | 1.59x10–22 |
kgp6448962 | rs57573303 | 9 | 28322259 | NM_001012978 | BEX5 | X | 5.84x10–22 |
rs3803712 | rs3803712 | 16 | 26074500 | NM_001712 | CEACAM1 | 19 | 7.21x10–22 |
kgp36317 | rs2247335 | 6 | 106992592 | NM_001007234 | ERCC8 | 5 | 8.83x10–22 |
kgp4630305 | rs59557850 | 8 | 78148122 | NM_003728 | UNC5C | 4 | 1.10x10–21 |
rs9655226 | rs9655226 | 7 | 22598742 | NM_170695 | TGIF1 | 18 | 3.07x10–21 |
kgp10592712 | rs73063011 | 19 | 52338183 | NM_024032 | C17ORF53 | 17 | 8.71x10–21 |
kgp237322 | rs539822 | 5 | 176310164 | XM_001721497 | LOC100132457 | 2 | 1.02x10–20 |
rs11053624 | rs11053624 | 12 | 10283711 | NM_015589 | SAMD4A | 14 | 1.51x10–20 |
kgp11540460 | rs144298037 | 6 | 45434746 | NM_001004349 | FLJ45422 | 6 | 1.56x10–20 |
kgp11526978 | rs4711691 | 6 | 12404895 | NM_014453 | CHMP2A | 19 | 3.55x10–20 |
kgp11514400 | rs35833993 | 6 | 165457847 | NM_006918 | SC5D | 11 | 5.65x10–20 |
kgp3001132 | rs9606166 | 22 | 19811720 | NM_006704 | SUGT1 | 13 | 6.90x10–20 |
kgp9305036 | rs943009 | 6 | 11243891 | NR_002940 | LRRC37A4 | 17 | 1.59x10–19 |
kgp8789955 | rs62576233 | 9 | 84337468 | NM_005792 | MPHOSPH6 | 16 | 1.63x10–19 |
kgp1173427 | rs61733660 | 6 | 151148947 | XM_925998 | SRA1 | 5 | 1.82x10–19 |
rs2968402 5 | rs2968402 4 | 16 | 21947480 | NM_014598 | SOCS7 | 17 | 3.16x10–19 |
kgp12304307 | rs13298711 | 9 | 83820909 | NM_002256 | KISS1 | 1 | 3.45x10–19 |
rs11636802 | rs11636802 | 15 | 56775597 | DA276856 | HS.576243 | 1 | 3.53x10–19 |
kgp12481432 | rs4407201 | 2 | 130522894 | NM_016134 | CPQ | 8 | 4.88x10–19 |
kgp31122632 | rs138131809 | X | 116143012 | NR_024524 | LOC100129055 | 10 | 6.25x10–19 |
rs7149078 | rs7149078 | 14 | 32844576 | CD369504 | HS.540642 | 16 | 6.57x10–19 |
kgp4554682 | rs1108962 | 4 | 100663492 | AI274046 | HS.555512 | 14 | 8.86x10–19 |
kgp8947215 | rs73030956 | 12 | 1675847 | NM_018271 | FLJ10916 | 2 | 9.40x10–19 |
kgp7059559 | rs1831464 | 13 | 92902619 | NM_019062 | RNF186 | 1 | 9.67x10–19 |
kgp4609959 | rs13284671 | 9 | 824742 | NM_002720 | PPP4C | 16 | 1.02x10–18 |
kgp2913569 | rs36067040 | 1 | 224238495 | NM_001017977 | DCAF6 | 1 | 1.32x10–18 |
kgp1360358 | rs35447805 | 8 | 85131756 | NM_005533 | IFI35 | 17 | 1.67x10–18 |
kgp6643156 | rs79321471 | 14 | 101498881 | NM_017831 | RNF125 | 18 | 1.81x10–18 |
kgp619464 | rs4292995 | 1 | 30738298 | NM_022148 | CRLF2 | Y | 2.36x10–18 |
rs6074541 | rs6074541 | 20 | 12978517 | NM_006286 | TFDP2 | 3 | 2.87x10–18 |
kgp12299095 | rs35007051 | 2 | 188415764 | NM_002164 | IDO1 | 8 | 3.76x10–18 |
kgp12307971 | rs76107005 | 10 | 85534815 | NM_002201 | ISG20 | 15 | 4.36x10–18 |
kgp10871570 | rs115462216 | 21 | 22882926 | U43604 | HS.550193 | 5 | 4.78x10–18 |
rs3025651 | rs3025651 | 6 | 29539914 | NM_003646 | DGKZ | 11 | 6.03x10–18 |
List of the top 50 significant interactions. Regulated transcripts and respective p-values are shown.
SNP with the most significant association obtained from comparison of all BMS (N = 22) and AMS (N = 23) offspring was shown for each transcript.
1 SNP ID as defined by Illumina HumanOmni-5-Quad BeadChip annotation.
2 Genome build 37.
3 RefSeq or UniGene nomenclature.
4 P-values for differences between regression slopes (BMS vs. AMS) obtained from an additive model.
5 SNP mapped at two locations (chr16:21947480 and chr16:29119905). Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome.