Table 1. Clinicopathological features of 232 patients who received curative hepatectomy.
| Variable | No recurrence | ER | LR | P1 value | P2 value |
|---|---|---|---|---|---|
| N (%) | 85 | 99 | 48 | ||
| CRP (mg/dl) | 1.5 ± 0.9 | 2.0 ± 1.0 | 2.2 ± 1.4 | <0.001* | <0.001* |
| Age (yrs)a | 50.1 ± 6.6 | 51.4 ± 6.7 | 50.8 ± 7.1 | 0.184 | 0.562 |
| Gender (male: female) | 73:12 | 80:19 | 41:7 | 0.359 | 0.941 |
| Child’s class (A: B) | 58:27 | 76:23 | 34:14 | 0.195 | 0.755 |
| Cirrhosis (present: absent) | 75:10 | 91:8 | 45:3 | 0.402 | 0.304 |
| ALT (IU/L)a | 77.6 ± 30.0 | 76.7 ± 27.0 | 71.9 ± 30.7 | 0.834 | 0.301 |
| AST (IU/L)a | 65.5 ± 26.3 | 63.3 ± 25.9 | 62.7 ± 26.5 | 0.555 | 0.554 |
| Total bilirubin (mg/dL)a | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 | 0.327 | 0.321 |
| Albumin (g/dL)a | 3.9 ± 0.2 | 3.9 ± 0.2 | 4.0 ± 0.2 | 0.855 | 0.207 |
| Platelet count (104/mm3)a | 14.5 ± 4.0 | 15.4 ± 4.2 | 15.4 ± 3.9 | 0.139 | 0.241 |
| Maximal tumor dimension (cm)a | 5.4 ± 2.0 | 6.2 ± 2.0 | 6.2 ± 2.3 | 0.008* | 0.030* |
| Tumor number (multiple: solitary) | 56:29 | 72:27 | 41:7 | 0.314 | 0.015* |
| Micrometastasis (present: absent) | 44:41 | 51:48 | 22:26 | 0.973 | 0.511 |
| Macroscopic vascular invasion (present: absent) | 40:45 | 44:55 | 22:26 | 0.723 | 0.892 |
| Invasion to the portal vein (present: absent) | 12:73 | 28:71 | 9:39 | 0.020* | 0.471 |
| Anatomic resection (yes: no) | 56:29 | 61:38 | 34:14 | 0.549 | 0.558 |
| Histology, n (%) | 0.025* | 0.784 | |||
| Well differentiated | 32 (37.6) | 25 (25.3) | 16 (33.3) | ||
| Moderately differentiated | 32 (37.6) | 31 (31.3) | 21 (43.8) | ||
| Poorly differentiated | 21 (24.7) | 43 (43.4) | 11 (22.9) |
ER: early recurrence; LR: late recurrence; CRP: C-reactive protein; ALT: alanine aminotransferase; AST: aspartate aminotransferase.
a Values shown are the mean±standard deviation
* Significant difference.
P1 value: comparison between ER group and control group, P2 value: comparison between LR group and control group.