Table 1.

Phenotypes of mouse models of DNA repair and inflammation.

Gene	Role of gene product	Phenotype of mouse deletion	References
AAG/MPH	Alkyladenine DNA glycosylase	Inflammation and colon cancer upon treatment with DSS/AOM	Meira et al., 2008
ALKBH2 ALKBH3	Direct reversal of alkyation; repair of ethenobases	Inflammation and colon cancer upon treatment with AOM plus DSS; lethal in combination with AAG-deletion in the presence of AOM plus DSS	Calvo et al., 2012
OGG1	DNA glycosylase that removes 8-oxoG and Fapy G	Inflammation resistant; moderate tumorigenesis	Klungland et al., 1999; Minowa et al., 2000; Mabley et al., 2005; Bacsi et al., 2013
MUTYH	DNA glycosylase that removes adenine opposite 8-oxoG	Intestinal adenomas with G:C to T:A mutations in the APC gene; mice doubly deficient in OGG1 and MUTYH are predisposed to lung and ovarian tumors	Sakamoto et al., 2007; Russo et al., 2004
NEIL1 NTH1	DNA glycosylases that removed oxidized bases	Mice doubly deleted of these glycosylases develop lung and liver tumors	Chan et al., 2009
FANC C	Member of Fanconi Anemia crosslink repair pathway	Hypersensitive to LPS-induced inflammation intrinsic to hematopoietic system.	Sejas et al., 2007; Du et al., 2014
SMAD4	Regulator of TGF-β signaling	Inflammation and spontaneous head and neck cancer	Bornstein et al., 2009
RAG2	Adaptive immune response; V(D)J recombination	Infection with Helicobacter hepaticus leads to inflammation and colon cancer	Mangerich et al., 2012
IL 10	Suppressor of macrophage induction; inhibitor of proinflammatory cytokines	Spontaneous chronic inflammation and colon cancer that depends on commensal bacteria	Kuhn et al., 1993
T-bet	T box transcription factor	Spontaneous colitis	Garrett et al., 2007