Table 1.
Genotype and minor allele frequencies for the MTHFR and MTR single-nucleotide polymorphisms (SNPs) in the MASTOS study
| Gene/SNP | Cases | Controls |
|---|---|---|
| MTHFR 677C>T (rs1801133) | ||
| C/C | 361 | 437 |
| C/T | 516 | 526 |
| T/T | 188 | 194 |
| MAFa | 0.42 | 0.39 |
| Hardy–Weinberg (P value)b | 0.10 | |
| MTHFR 1298A>C (rs1801131) | ||
| A/A | 138 | 150 |
| A/C | 465 | 501 |
| C/C | 468 | 486 |
| MAFa | 0.65 | 0.65 |
| Hardy–Weinberg (P value)b | 0.24 | |
| MTR 2756A>G (rs1805087) | ||
| A/A | 679 | 684 |
| A/G | 350 | 404 |
| G/G | 45 | 68 |
| MAFa | 0.2 | 0.23 |
| Hardy–Weinberg (P value)b | 0.41 | |
a MAF minor allele frequency
b P value from Chi-square test performed for Hardy–Weinberg equilibrium (HWE) evaluation