Table 3.
Studies Comparing Surrogate Measures of Volume Management in CAPD and APD
| Study (Year) | Study Design | Setting | Data Source | N (CAPD, APD) | F/U | Outcome |
|---|---|---|---|---|---|---|
| de Fijter et al19 (1994) | RCT | Netherlands (1988–1991) | Single center | 82 (41, 41) | 24 mo | No difference in MAP or mean dry weight over time; antihypertensive drugs used in 60% of CAPD and 74% of APD |
| Bro et al22 (1999) | RCT | Denmark (1995–1999) | Multicenter | 34 (17, 17) | 6 mo | No episodes of weight > 2 kg above dry weight in CAPD group; 2 cases in APD group; mean SBP similar in both groups |
| Frankenfield et al34 (1999) | Retrospective study | US (1995–1997) | Multicenter | ~1,200 (~700, ~500) | 3 different 2-mo periods | No significant difference in proportion of individuals with hypertension |
| Ortega et al39 (2001) | Prospective cohort study | Spain (2001) | Single center | 36 (16, 20) | 24 h (Na balance studies) | In CAPD, daily peritoneal Na removal and net ultrafiltration volume significantly higher and SBP lower |
| Rodriguez-Carmona & Fontan40 (2002) | Baseline cross-sectional data and prospective cohort study | Spain (2002) | — | 141 (63, 78); 32 before and after change from CAPD to APD | 3 mo, 24-h collections for Na balance | In CAPD, Na removal significantly greater, independent of ultrafiltration volume; Na removal decreased significantly after switching from CAPD to APD |
| Rodriguez-Carmona et al26 (2004) | Prospective cohort study | Spain (1998–2002) | Single center | 104 (53, 51) | 12–24 mo | In APD, ultrafiltration and Na removal rates consistently and significantly lower; in CAPD, better SBP control |
| Bavbek et al41 (2007) | Cross-sectional study | Turkey (2007) | 2 centers | 62 (32, 30) | — | In APD, significantly lower daily ultrafiltration volume, higher serum brain natriuretic peptide, and LVM index; no significant difference in BP |
| Davison et al42 (2009) | Cross-sectional study | Canada (2004–2006) | Single center | 158 (90, 68) | — | No significant difference in Na removal, ultrafiltration, or BP between groups; liberal use of icodextrin, limited no. of nocturnal exchanges and supplemental daytime exchange in APD group |
| Van Biesen et al43 (2011) | Cross-sectional study | Europe (NR) | Multicenter | 661 (53% APD) | — | Excluded those without access to icodextrin; PD modality not associated with extracellular volume excessa |
| Cnossen et al44 (2012) | Cross-sectional study | Netherlands (NR) | Multicenter | 44 (24, 20) | ~21–30 mo | In APD, lower total Na removal; no statistically significant difference in SBP, ultrafiltration volumes, or brain natriuretic peptide ultrafiltration |
Abbreviations: APD, automated peritoneal dialysis; BP, blood pressure; CAPD, continuous ambulatory peritoneal dialysis; F/U, follow-up; LVM, left ventricular mass; MAP, mean arterial pressure; Na, sodium; NR, not reported; PD, peritoneal dialysis; RCT, randomized controlled trial; SBP, systolic blood pressure.
a
As measured by bioimpedance.