Figure 7.

Membrane potential dynamics of pyramidal cells and interneurons during Up states. A, Mean total membrane potential SDs of pyramidal cells and interneurons. Up-state membrane potential SDs are expressed as multiples of Down-state membrane potential SDs (e.g., a value of σ_Up/σ_Down = 5 indicates that the membrane potential SD was 5 times higher during the Up state than during the Down state). Error bars indicate SEM. B, Mean time-dependent SDs of the membrane potential of pyramidal cells and interneurons. SDs are plotted as a function of the fraction of the Up state (i.e., the time axis is normalized from 0 to 1 to average across recordings with different Up-state durations). Shading represents SEM. The following comparisons were significant (Kruskal–Wallis test, Bonferroni correction): σ_{L5 Pyr, RS} < σ_{L2/3 PV} (p = 0.0018), σ_{L5 Pyr, RS} > σ_{L2/3 SOM} (0.0030), σ_{L5 Pyr, RS} > σ_{L2/3 VIP} (0.011), σ_{L2/3 Pyr} > σ_{L2/3 PV} (3.0 × 10⁻⁴), σ_{L2/3 Pyr} > σ_{L5 SOM} (0.0030), σ_{L2/3 Pyr} > σ_{L2/3 SOM} (2.9 × 10⁻⁴), σ_{L2/3 Pyr} > σ_{L2/3 VIP} (3.9 × 10⁻⁵), σ_{L2/3 Pyr} > σ_{L2/3 NPY} (0.017), σ_{L5 PV} > σ_{L2/3 PV} (7.3 × 10⁻⁴), σ_{L5 PV} > σ_{L2/3 SOM} (0.0037), σ_{L5 PV} > σ_{L2/3 VIP} (0.015), σ_{L2/3 PV} > σ_{L5 SOM} (2.3 × 10⁻⁶), σ_{L2/3 PV} > σ_{L2/3 SOM} (4.8 × 10⁻⁹), σ_{L2/3 PV} > σ_{L2/3 VIP} (7.0 × 10⁻¹⁰), σ_{L2/3 PV} > σ_{L2/3 NPY} (1.7 × 10⁻⁸).