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. 2015 Jan 21;35(3):1149–1159. doi: 10.1523/JNEUROSCI.3490-14.2015

Figure 2.

Figure 2.

Emergence of β-band oscillations in a dopamine-depleted striatal network model. A, Raster plot of 200 MSNs in the normal striatal network (Control) in response to low (0.3; A1) and high (0.6; A2) cortical input correlation. B, Raster plot of 200 MSNs in the dopamine-depleted striatal network in response to low (0.3; B1) and high (0.6; B2) cortical input correlation. Raster plots depict the first second of the 2 s simulation, with spikes from D1 MSNs indicated in red and spikes from D2 MSNs indicated in blue. C, Power spectra of the normal striatal network in response to low (0.3; light gray) and high (0.6; black) cortical input correlation. The power of α- and β-band oscillations are higher in the network in response to high cortical input correlation. D, Power spectra of the dopamine-depleted striatal network in response to low (0.3; light green) and high (0.6; dark green) cortical input correlation. Power of α- and β-band oscillations are significantly increased in the dopamine depletion condition compared with the control condition, especially in response to high cortical input correlation. E, F, Plot of β-band oscillation power versus cortical input correlation for D1 MSNs, D2 MSNs, and all MSNs for the control (E) and dopamine depletion (F) conditions. MSNs have a higher power of β-band oscillations and an increased sensitivity to changes in cortical input correlation in the dopamine depletion condition compared with control. β-Band power of D2 MSNs increases more than that of D1 MSNs in the transition from control to dopamine depletion. G, Higher β-band power of MSNs in the dopamine depletion condition compared with the control condition in response to different input frequencies (5, 7, and 10 Hz). The effect is robust to changes in input frequency. The cortical input correlation is 0.6. H, Percentage difference in firing between D1 and D2 MSNs in the control and dopamine depletion conditions in response to different input frequencies (5, 7, and 10 Hz). The percentage difference is calculated as difference divided by mean firing of D1 MSNs. The imbalance in firing between the two MSN classes is also robust to changes in input frequency. The cortical input correlation is 0.6. Error bars represent SEM. ctx corr, Cortical correlation.