Figure 1.

Signaling connections. A, BDNF stimulates ERK signaling, and thus MNK1 and eIF4E phosphorylation, as well as mTORC1 and the phosphorylation of 4E-BP2. B, Phosphorylation of 4E-BP2 by mTORC1 leads to its dissociation from eIF4E, which can then bind other partners. C, MNK1 phosphorylates eIF4E, and causes the dissociation of eIF4E from CYFIP1. It is not clear whether phosphorylation of eIF4E itself regulates this interaction or whether MNK-mediated phosphorylation of, e.g., CYFIP1, is also involved. Gray color indicates potential, rather than established, links.