Table 3. Pharmacokinetic parameters (mean ± SD) of vincristine sulfate after its intravenous administration at a dose of 0.7 mg/m2 to dogs with TVT (n=6).
| Pharmacokinetic parameters (units) | Average ± SD |
|---|---|
| K12 (min–1) | 0.094 ± 0.035 |
| K21 (min–1) | 0.029 ± 0.012 |
| Cp0 (ng/ml) | 119 ± 18.0 |
| t½α (min) | 21.5 ± 6.90 |
| t½β (min) | 47.6 ± 14.2 |
| Cl (l/min/kg) | 0.010 ± 0.001 |
| Vd(area) (l/kg) | 0.660 ± 0.210 |
| MRT (min) | 55.9 ± 19.3 |
| AUC (ng·min/ml) | 2,349 ± 317 |
K12, K21= micro-rate constants; Cp0= plasma concentration at initial time; t1/2α= distribution half-life; t1/2β = elimination half-life; Cl = clearance; Vd(area) = volume of distribution; MRT = mean residence time; AUC = area under the plasma concentration-time curve.