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Loperamide impaired cell viability following 72 hr of incubation in a dose dependent fashion in CTAC, D-17, CML-1 and CMT-12 canine cancer cell lines. Viability data were garnered from experiments performed in triplicate and assessed by Alamar Blue assay. Cell viability for both CTAC and CMT-12 was significantly lower than control cells at concentrations ≥32 µM; cell viability for D-17 and CML-1 was significantly lower than control cells at concentrations ≥10 µM.
