Table 2. Induction of apoptosis following incubation with loperamide.

	CTAC	D-17	CML-1	CMT-12
6 hr
0 µM	2.6 ± 0.8	6.1 ± 1.7	1.9 ± 0.5	9.7 ± 1.5
10 µM	1 ± 0.2	7.6 ± 1.3	2.4 ± 0.6	8.6 ± 0.6
30 µM	2.8 ± 0.5	5.8 ± 0.2	3.5 ± 1.6	10.8 ± 3.2
24 hr
0 µM	1.5 ± 0.5	2.2 ± 0.6	1.5 ± 0.3	9.1 ± 2.6
10 µM	3.2 ± 0.9	2.4 ± 1	1.4 ± 0.3	6.2 ± 1.7
30 µM	39.9 ± 6.1*	27.6 ± 7.3*	46.5 ± 13.5*	25.5 ± 4.4*
48 hr
0 µM	4.1 ± 1.6	1.1 ± 0.2	1.8 ± 0.5	7.1 ± 0.7
10 µM	6.2 ± 2	1.4 ± 0.4	1.4 ± 0.2	9 ± 0.9
30 µM	92.7 ± 0.1*	57.2 ± 4.6*	86.1 ± 3.5*	72.8 ± 2.3*

Percentage of cells undergoing apoptosis at three different time points and three different loperamide concentrations. Values are expressed as mean ± SEM from three independent experiments. An * indicates that there are significantly more apoptotic cells compared to the control (0 µM of drug) as analyzed via ANOVA with Tukey post-hoc test.