Table 3. Percentage of cells in G0/G1 following incubation with loperamide.
CTAC | D-17 | CML-1 | CMT-12 | |
---|---|---|---|---|
6 hr | ||||
0 µM | 48.5 ± 3.1 | 45.8 ± 1.2 | 54.6 ± 0.3 | 49.7 ± 1.4 |
10 µM | 50 ± 2 | 44.5 ± 0.5 | 55.8 ± 1.2 | 51.5 ± 2 |
30 µM | 41.3 ± 1.1 | 44.8 ± 0.6 | 59.7 ± 1.3 | 49 ± 2.3 |
24 hr | ||||
0 µM | 38.1 ± 3.3 | 52.6 ± 1.5 | 50.6 ± 0.3 | 58.7 ± 1 |
10 µM | 53.5 ± 2.1 | 55.5 ± 2.2 | 57.2 ± 1.6 | 59.6 ± 0.2 |
30 µM | 56.8 ± 0.8* | 63.4 ± 3.7* | 70 ± 1.9* | 78.2 ± 2.4* |
48 hr | ||||
0 µM | 52.7 ± 5.1 | 54.4 ± 1.2 | 49.7 ± 3.1 | 80.4 ± 1.1 |
10 µM | 51.2 ± 1.6 | 60.7 ± 1.8 | 50.3 ± 1.8 | 77.6 ± 2 |
30 µM | 62.8 ± 2.4* | 78.8 ± 1.1* | 71.6 ± 0.8* | 85.7 ± 1.7* |
Percentage of cells in G0/G1 at three different time points and three different loperamide concentrations. Values are expressed as mean ± SEM from three independent experiments. An * indicates that there are significantly more G0/G1 cells compared to the control (0 µM of drug) as analyzed via ANOVA with Tukey post-hoc test.