Table 1. QRDR mutation genotypes and fluoroquinolone MICs and MPCs for Pm field strains.

Mutation type	Number of strains	MIC range (µg/ml)			Substitution in		MPC range a) (µg/ml)/ MSW b)
		CIP	ENR	ORB	gyrA	parC	CIP	ENR	ORB
Wild	9	0.03–0.25	0.03–0.25	0.03–0.06	None	None	0.125–0.5 / 0.06–0.25	0.125–0.5 / 0.06–0.25	0.125–0.5 / 0.06–1.9
I	13	0.5	0.5	0.25–0.5	Asp87 to Asn	None	4–16 / 3.5–15.5	8–32 / 3.5–31.5	4–32 / 3.5–31.5
II	1	0.5	0.5	0.5	Ala84 to Pro	None	4/ 3.5	16/ 15.5	32/ 31.5

a) MPCs, mutant prevention concentrations were determined on Mueller-Hinton plates for ciprofloxacin (CIP), enrofloxacin (ENR) and orbifloxacin (ORB). b) MSW, mutant selection window (antibiotic concentration found between the minimum inhibitory concentration and MPC).