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. 2014 Oct 27;125(2):370–382. doi: 10.1182/blood-2014-05-575225

Figure 6.

Figure 6

Overexpression of T-bet in lymphocytes initiates PAP development. (A) Diagram of the experimental design. (B) Representative photomicrographs of the lung sections from Rag2−/− recipients transplanted with splenocytes from WT, T-bettg/wt, or T-bettg/tg mice. H&E (top panels) and PAS (bottom panels) staining. Bars = 100 µm. (C) Changes in WBC counts in PB from Rag2−/− recipients after transplantation of WT or T-bettg/tg splenocytes. (D-E) Changes in the numbers of inflammatory monocytes and neutrophils (D), and of T cells and B cells (E), in the PB of Rag2−/− recipients after transplantation of WT or T-bettg/tg splenocytes. Symbols are means ± SD; n = 4 and 8. ***P < 0.001; **P < .01; *P < .05 (Student t test).