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. Author manuscript; available in PMC: 2015 Jan 21.
Published in final edited form as: Nat Struct Mol Biol. 2014 Mar 23;21(4):366–374. doi: 10.1038/nsmb.2796

Figure 8. Targeting of HR at transcriptionally active loci.

Figure 8

The trimethylation of histone H3 on the lysine 36 (H3K36me3), a mark associated with transcriptional elongation, would be recognized by LEDGF, itself interacting with CtIP, thus bringing to the site of break a resection promoting factor. This would subsequently trigger RAD51 binding and HR repair on actively transcribed genes. DSBs occurring within inactive genes or intergenic regions would be unable to recruit a resection factor thus leading to repair by NHEJ.