Table 1.
Baseline characteristics of the examined groups
| Hypertensives | Normotensives | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| ACEI | HCTZ | EPT+ | EPT− | p | |||||
| EPT+ | EPT− | p | EPT+ | EPT− | p | ||||
| BP measurements | |||||||||
| mSBP (mmHg) | 161.2 ± 9.6* | 162.2 ± 9.8* | NS | 159.7 ± 7.6* | 160.4 ± 9.0* | NS | 136.2 ± 2.5 | 136.5 ± 3.0 | NS |
| mDBP (mmHg) | 97.8 ± 2.4* | 98.9 ± 3.1* | NS | 97.1 ± 2.7* | 98.4 ± 3.5* | NS | 85.0 ± 2.6 | 85.6 ± 2.6 | NS |
| mSBP24 (mmHg) | 149.2 ± 6.3* | 148.1 ± 6.9* | NS | 149.0 ± 6.1* | 148.5 ± 7.0* | NS | 129.4 ± 2.7 | 129.9 ± 2.6 | NS |
| mDBP24 (mmHg) | 92.5 ± 1.5* | 92.8 ± 1.9* | NS | 92.7 ± 1.6* | 92.9 ± 1.6* | NS | 82.9 ± 2.3 | 83.6 ± 2.3 | NS |
| Fall SBP24 (%) | 7.0 ± 2.6* | 7.1 ± 3.1* | NS | 7.0 ± 2.2* | 7.8 ± 3.2* | NS | 9.9 ± 1.9 | 9.9 ± 1.9 | NS |
| Fall DBP24 (%) | 6.2 ± 1.8* | 5.9 ± 1.8* | NS | 6.4 ± 2.0* | 6.5 ± 2.4* | NS | 10.1 ± 2.1 | 10.6 ± 2.7 | NS |
| Metabolic parameters | |||||||||
| Lipid profile | |||||||||
| Total cholesterol (mmol/L) | 5.9 ± 0.4 | 6.0 ± 0.4 | NS | 5.8 ± 0.5 | 6.0 ± 0.4 | NS | 5.9 ± 0.5 | 5.8 ± 0.4 | NS |
| LDL cholesterol (mmol/L) | 3.7 ± 0.5 | 3.9 ± 0.4 | NS | 3.7 ± 0.5 | 3.9 ± 0.4 | NS | 3.8 ± 0.5 | 3.7 ± 0.4 | NS |
| HDL cholesterol (mmol/L) | 1.4 ± 0.1 | 1.4 ± 0.1 | NS | 1.4 ± 0.1 | 1.4 ± 0.1 | NS | 1.4 ± 0.1 | 1.3 ± 0.1 | NS |
| Triglycerides (mmol/L) | 1.7 ± 0.1 | 1.7 ± 0.1 | NS | 1.7 ± 0.1 | 1.7 ± 0.2 | NS | 1.6 ± 0.2 | 1.7 ± 0.1 | NS |
| Glucose (mmol/L) | 5.3 ± 0.6 | 5.5 ± 0.6 | NS | 5.2 ± 0.6 | 5.5 ± 0.6 | NS | 5.4 ± 0.6 | 5.3 ± 0.6 | NS |
| Insulin (µI/L) | 19.1 ± 6.4* | 19.7 ± 7.3* | NS | 19.6 ± 4.8* | 20.3 ± 7.8* | NS | 16.4 ± 5.1 | 17.0 ± 6.4 | NS |
| Uric acid (mg/dL) | 6.2 ± 2.1* | 6.2 ± 2.0* | NS | 6.2 ± 1.6* | 6.4 ± 2.1* | NS | 5.0 ± 1.4 | 5.0 ± 1.2 | NS |
| Hemodynamic parameters | |||||||||
| PWV (m/s) | 10.7 ± 1.7* | 10.8 ± 1.4* | NS | 10.8 ± 1.6* | 10.8 ± 2.1* | NS | 8.9 ± 1.5 | 8.6 ± 1.1 | NS |
| RPF (mL/min) | 421.9 ± 81.1* | 423.7 ± 74.2* | NS | 426.3 ± 66.0* | 423.0 ± 75.1* | NS | 488.7 ± 47.3 | 496.6 ± 45.0 | NS |
| GFR (mL/min) | 105.9 ± 7.5* | 104.7 ± 7.7* | NS | 106.9 ± 5.8* | 105.2 ± 5.7* | NS | 115.1 ± 5.2 | 114.8 ± 5.9 | NS |
mSBP/mDBP mean systolic/diastolic blood pressure in office measurement, mSBP 24 /mDBP 24 mean systolic/diastolic blood pressure in 24-hour ambulatory monitoring, Fall SBP 24 /Fall DBP 24 day-night fall of systolic/diastolic blood pressure in 24-hour ambulatory monitoring
* p < 0.05–0.0001 values that are, at baseline, significantly different in comparison to hypertensives ACEI (EPT+; EPT−) and HCTZ (EPT+; EPT−) vs. normotensives (EPT+; EPT), respectively