Table 3.
The influence of EPT on mean values (±standard deviation) of different analyzed parameters after 12-month follow-up period
| Hypertensives | Normotensives | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| ACEI | HCTZ | EPT+ | EPT− | p | |||||
| EPT+ | EPT− | p | EPT+ | EPT− | p | ||||
| BP measurements | |||||||||
| mSBP (mmHg) | 132.2 ± 3.2* | 134.3 ± 3.1* | <0.001 | 133.8 ± 5.6* | 134.0 ± 4.0 * | NS | 130.9 ± 3.4* | 136.6 ± 2.2 | <0.0001 |
| mDBP (mmHg) | 85.3 ± 2.3* | 84.4 ± 2.6* | <0.05 | 85.3 ± 3.8* | 85.1 ± 2.4* | NS | 81.4 ± 2.4* | 84.8 ± 2.2 | <0.0001 |
| ΔSBP24 (mmHg) | 23.4 ± 5.8 | 21.1 ± 8.1 | NS | 22.1 ± 8.2 | 21.6 ± 7.1 | NS | 2.6 ± 2.7 | 2.2 ± 3.9 | NS |
| ΔDBP24 (mmHg) | 9.2 ± 2.5 | 10.0 ± 2.7 | NS | 8.7 ± 2.8 | 9.8 ± 2.6 | NS | 0.8 ± 2.9 | 0.5 ± 3.1 | NS |
| mSBP24 (mmHg) | 125.8 ± 2.1* | 127.0 ± 3.3* | NS | 126.9 ± 3.0* | 126.7 ± 2.5* | NS | 126.8 ± 2.8* | 127.8 ± 3.4 | NS |
| mDBP24 (mmHg) | 83.8 ± 1.7* | 82.8 ± 1.8* | NS | 84.7 ± 2.0* | 83.1 ± 1.8* | NS | 82.1 ± 1.9 | 83.1 ± 1.8 | NS |
| Fall SBP24 (%) | 11.3 ± 1.7* | 10.9 ± 2.5* | NS | 9.6 ± 2.0* | 8.6 ± 1.6 | NS | 11.4 ± 1.8* | 9.5 ± 1.5 | 0.001 |
| Fall DBP24 (%) | 11.1 ± 1.6* | 10.9 ± 1.8* | NS | 9.5 ± 2.0* | 9.0 ± 1.6 | NS | 11.8 ± 1.6 | 9.2 ± 1.8 | 0.001 |
| Metabolic parameters | |||||||||
| Lipid profile (mmol/L) | |||||||||
| Total cholesterol | 5.5 ± 0.3* | 5.8 ± 0.3* | <0.01 | 5.8 ± 0.5 | 6.2 ± 0.8 | NS | 5.6 ± 0.2* | 6.0 ± 0.5 | <0.001 |
| LDL cholesterol | 3.4 ± 0.2* | 3.6 ± 0.3* | <0.01 | 3.7 ± 0.5 | 4.1 ± 0.9 | NS | 3.4 ± 0.2* | 3.9 ± 0.5 | <0.01 |
| HDL cholesterol | 1.4 ± 0.1 | 1.4 ± 0.1 | NS | 1.4 ± 0.1 | 1.4 ± 0.1 | NS | 1.4 ± 0.1 | 1.4 ± 0.1 | NS |
| Triglycerides | 1.6 ± 0.1 | 1.7 ± 0.1 | NS | 1.7 ± 0.1 | 1.7 ± 0.1 | NS | 1.7 ± 0.2 | 1.7 ± 0.1 | NS |
| Glucose (mmol/L) | 5.4 ± 0.6 | 5.4 ± 0.6 | NS | 5.4 ± 0.6 | 5.6 ± 0.5 | NS | 5.4 ± 0.6 | 5.5 ± 0.6 | NS |
| Insulin (µI/L) | 14.4 ± 3.7* | 16.8 ± 5.5* | NS | 16.4 ± 5.1* | 23.8 ± 8.4* | <0.01 | 12.7 ± 3.9* | 16.6 ± 4.9 | <0.01 |
| Uric acid (mg/dL) | 4.7 ± 1.3 | 5.3 ± 1.5 | NS | 5.4 ± 1.3 | 7.5 ± 2.3* | <0.001 | 3.8 ± 1.0* | 5.1 ± 1.1 | <0.001 |
| Hemodynamic parameters | |||||||||
| PWV (m/s) | 8.8 ± 1.6* | 9.0 ± 1.5* | NS | 9.3 ± 1.3* | 11.5 ± 2.5 | <0.01 | 7.8 ± 1.2* | 8.8 ± 1.4 | <0.05 |
| RPF (mL/min) | 519.4 ± 58.3* | 488.7 ± 59.0* | NS | 474.4 ± 57.5* | 336.2 ± 49.1* | <0.001 | 538.8 ± 30.2* | 485.0 ± 37.8 | <0.0001 |
| GFR (mL/min) | 106.5 ± 7.1 | 106.8 ± 5.7 | NS | 105.2 ± 4.7 | 105.8 ± 4.9 | NS | 117.0 ± 5.0 | 114.5 ± 5.7 | NS |
mSBP; mDBP mean systolic; mean diastolic blood pressure in office measurement, ΔSBP 24; ΔDBP 24 difference in mean systolic; diastolic blood pressure in 24-hour ambulatory monitoring after 12 months in comparison to baseline, mSBP 24 /mDBP 24 mean systolic/diastolic blood pressure in 24-hour ambulatory monitoring, Fall SBP 24 /Fall DBP 24 day-night fall of systolic/diastolic blood pressure in 24-hour ambulatory monitoring
* p < 0.05–0.0001 values that are significantly different in comparison to baseline