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. 2014 Sep 13;104(1):38–50. doi: 10.1007/s00392-014-0755-6

Table 3.

The influence of EPT on mean values (±standard deviation) of different analyzed parameters after 12-month follow-up period

Hypertensives Normotensives
ACEI HCTZ EPT+ EPT− p
EPT+ EPT− p EPT+ EPT− p
BP measurements
 mSBP (mmHg) 132.2 ± 3.2* 134.3 ± 3.1* <0.001 133.8 ± 5.6* 134.0 ± 4.0 * NS 130.9 ± 3.4* 136.6 ± 2.2 <0.0001
 mDBP (mmHg) 85.3 ± 2.3* 84.4 ± 2.6* <0.05 85.3 ± 3.8* 85.1 ± 2.4* NS 81.4 ± 2.4* 84.8 ± 2.2 <0.0001
 ΔSBP24 (mmHg) 23.4 ± 5.8 21.1 ± 8.1 NS 22.1 ± 8.2 21.6 ± 7.1 NS 2.6 ± 2.7 2.2 ± 3.9 NS
 ΔDBP24 (mmHg) 9.2 ± 2.5 10.0 ± 2.7 NS 8.7 ± 2.8 9.8 ± 2.6 NS 0.8 ± 2.9 0.5 ± 3.1 NS
 mSBP24 (mmHg) 125.8 ± 2.1* 127.0 ± 3.3* NS 126.9 ± 3.0* 126.7 ± 2.5* NS 126.8 ± 2.8* 127.8 ± 3.4 NS
 mDBP24 (mmHg) 83.8 ± 1.7* 82.8 ± 1.8* NS 84.7 ± 2.0* 83.1 ± 1.8* NS 82.1 ± 1.9 83.1 ± 1.8 NS
 Fall SBP24 (%) 11.3 ± 1.7* 10.9 ± 2.5* NS 9.6 ± 2.0* 8.6 ± 1.6 NS 11.4 ± 1.8* 9.5 ± 1.5 0.001
 Fall DBP24 (%) 11.1 ± 1.6* 10.9 ± 1.8* NS 9.5 ± 2.0* 9.0 ± 1.6 NS 11.8 ± 1.6 9.2 ± 1.8 0.001
Metabolic parameters
Lipid profile (mmol/L)
 Total cholesterol 5.5 ± 0.3* 5.8 ± 0.3* <0.01 5.8 ± 0.5 6.2 ± 0.8 NS 5.6 ± 0.2* 6.0 ± 0.5 <0.001
 LDL cholesterol 3.4 ± 0.2* 3.6 ± 0.3* <0.01 3.7 ± 0.5 4.1 ± 0.9 NS 3.4 ± 0.2* 3.9 ± 0.5 <0.01
 HDL cholesterol 1.4 ± 0.1 1.4 ± 0.1 NS 1.4 ± 0.1 1.4 ± 0.1 NS 1.4 ± 0.1 1.4 ± 0.1 NS
 Triglycerides 1.6 ± 0.1 1.7 ± 0.1 NS 1.7 ± 0.1 1.7 ± 0.1 NS 1.7 ± 0.2 1.7 ± 0.1 NS
 Glucose (mmol/L) 5.4 ± 0.6 5.4 ± 0.6 NS 5.4 ± 0.6 5.6 ± 0.5 NS 5.4 ± 0.6 5.5 ± 0.6 NS
 Insulin (µI/L) 14.4 ± 3.7* 16.8 ± 5.5* NS 16.4 ± 5.1* 23.8 ± 8.4* <0.01 12.7 ± 3.9* 16.6 ± 4.9 <0.01
 Uric acid (mg/dL) 4.7 ± 1.3 5.3 ± 1.5 NS 5.4 ± 1.3 7.5 ± 2.3* <0.001 3.8 ± 1.0* 5.1 ± 1.1 <0.001
Hemodynamic parameters
 PWV (m/s) 8.8 ± 1.6* 9.0 ± 1.5* NS 9.3 ± 1.3* 11.5 ± 2.5 <0.01 7.8 ± 1.2* 8.8 ± 1.4 <0.05
 RPF (mL/min) 519.4 ± 58.3* 488.7 ± 59.0* NS 474.4 ± 57.5* 336.2 ± 49.1* <0.001 538.8 ± 30.2* 485.0 ± 37.8 <0.0001
 GFR (mL/min) 106.5 ± 7.1 106.8 ± 5.7 NS 105.2 ± 4.7 105.8 ± 4.9 NS 117.0 ± 5.0 114.5 ± 5.7 NS

mSBP; mDBP mean systolic; mean diastolic blood pressure in office measurement, ΔSBP 24; ΔDBP 24 difference in mean systolic; diastolic blood pressure in 24-hour ambulatory monitoring after 12 months in comparison to baseline, mSBP 24 /mDBP 24 mean systolic/diastolic blood pressure in 24-hour ambulatory monitoring, Fall SBP 24 /Fall DBP 24 day-night fall of systolic/diastolic blood pressure in 24-hour ambulatory monitoring

p < 0.05–0.0001 values that are significantly different in comparison to baseline