Fig. 1.

Study design. Hispanic subjects with CAD and treated with aspirin therapy were randomly assigned in a 1:1 fashion to one of two treatment sequences: either ticagrelor 180 mg LD and 90 mg twice-daily MD for 7–9 days, followed by a washout period and clopidogrel 600 mg LD and 75 mg once-daily MD for 7–9 days, or clopidogrel 600 mg LD and 75 mg once-daily MD for 7–9 days, followed by a washout period and ticagrelor 180 mg LD and 90 mg twice-daily MD for 7–9 days. Platelet reactivity assessment and ticagrelor plasma concentrations were measured at several timepoints around the LD and at the end of the MD phase. CAD coronary artery disease, LD loading dose, MD maintenance dose