Table II.
Overview of Base and Final Model Parameter Estimates
| Parameter | Base model [RSE]a | Final model [Bootstrap 90% CI] |
|---|---|---|
| ΘTVEmax | 0.34 [0.04;11.5] | 0.36 [0.05;0.81] |
| ΘEDK50/Emax b (μg) | 10.33 [0.64;20.02] | 8.66 [5.19;11.39] |
| ΘKDE (hr−1) | 54.46 [1.64;1806] | 52.46 [12.18;65.14] |
| ΘInt_Dis (disease intercept) (L) | 0.9 [0.3;2.99] | 1.16 [1.06;1.19] |
| Θ Slope_Dis (disease slope) (L/day) | −0.82 [−1.93;-0.02] | −0.596 [−0.214;] |
| ΘKin (L/day) | 0.04 [0.001;1.32] | 0.0004 [0.0001;0.0032] |
| Θseverity on Emax | – | 0.94 [0.08;0.99] |
| Θreversibility on Emax | – | 1.05 [1.02;1.52] |
| Θseverity on Int_Dis | – | 0.62 [0.22;0.84] |
| Θsex on Int_Dis | – | 0.82 [0.13;0.97] |
| ΘPICS on Int_Dis | – | 0.92 [0.77;0.94] |
| Θheight on Int_Dis | – | 1.90 [1.48;2.52] |
| Initial hazard term (β0) | 0.006 [0.0001;0.33] | 0.006 [0.000;0.041] |
| Proportional hazard term for informative dropout (β2) | −0.843 [−0.11;−1.57] | −0.880 [−0.19;−0.92] |
| IIVEDK50 (CV%) | 8 [0.01;15.9] | – |
| IIVEmax (CV%) | 76 [0;153] | 70 [32;108] |
| IIVInt_Dis (CV%) | 35 [0;81] | 25 [12;63] |
| IIVSlope_Dis (CV%) | 16 [0;33] | – |
| IIVKin (CV%) | 10 [3;19.7] | 8 [11;28] |
| σ (L) | 0.36 [0.021;0.39] | 0.13 [0.08;0.24] |
a RSE relative standard errors; values computed from standard error of estimates generated by covariance step in NONMEM
bEDK50 estimates were based on a parameterisation relative to Emax