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. 2014 Sep 5;32(2):516–527. doi: 10.1007/s11095-014-1481-5

Table III.

The Effect of Solutol® HS15 (Applied as 5.2 mM Solution in HBSS:HEPES, 25 mM, pH 7.4) on the Permeability In Polarised Calu-3 Cell Layers To Different Sized Proteins Employed as ‘Model Proteins’. Experiment Conducted at 37°C

Permeant Mw
(kDa)		 Papp Control
(×10−6 cm/s)		 Papp Solutol® HS15
(×10−6 cm/s)		 Papp enhancement ratio
Insulin 5.8 2.27 ± 0.44 6.08 (*) ± 1.93 2.68
hGH 22 1.81 ± 0.51 4.30 (*) ± 1.26 2.30
Albumin 66 1.26 ± 0.16 1.28 ± 0.26 1.02
IgG 150 0.59 ± 0.19 0.59 ± 0.16 1.00

Data expressed as Papp of permeant alone and following co-application with Solutol® HS15 (5.2 mM). (*) indicates statistically significant deviation, P < 0.001, N = 3 and n = 4