Table 3.

Writers and erasers in mammals

Modification	Writer	Eraser
DNA methylation	DNA methyltransferases: DNMT1, DNMT3A/3B	Enzymes of demethylation pathway: AID/APOBEC; DNA glycosylases: TDG, SMUF1, MBD4; TET family
Histone methylation	HMTs, lysine and arginine-specific	HDMs
Histone acetylation	HATs	HDACs
Histone phosphorylation	Kinases	Dephosphatases
Histone ubiquitination	Ubiquitin ligases	Isopeptidases
Histone sumoylation	Serin-specific peptidases (SENP)—remove C-terminal residue, ligases—catalyzed conjunction SUMO to lysine	Isopeptidases
Histone biotinylation	Biotinyl ligases: BTD, HCS	Debiotinidase: BTD?
Histone citrullination	Peptidylarginine deaminases: PADI2, PADI4
Histone ADP-ribosylation	ADP-ribosyltransferases (ARTs)	ADP-ribosyl hydrolases (ARHs) poly-(ADP rybosylase) glycohydrolase (PARD)
Histone β-N-glycosylation	Transferase: O-linked β-N-acetylglucosamine transferase (OGT)	Hydrolase: O-linked β-N-acetylglucosaminidase (OGA)
Histone prolinę isomerization	Proline isomerase: FK506 binding proteins (FKBPs)
Histone propionylation	Histone acetyltransferases: p300, CBP	HDACs
Histone butyrylation	Histone acetyltransferases: p300, CBP	HDACs