Table 4.
Readers of epigenetic modifications
| Recognition site | Reader domain | Protein | Modification |
|---|---|---|---|
| Methylcytosine | MBD | MBD1, MBD2, MBD4, MeCP2 | 5-methylcytosine (5mC) |
| SRS | UHRF1, UHRT2 | ||
| BTP/POZ-Zn-finger | Kasio, ZBTB4, ZBTB38 | ||
| IPT/TIG | RBP-J | ||
| Methyllysine | Chromobarrel (R) | MOF, Eaf3, MRG15, | H3K36me2/me3, H3K4me1, H4K20me1 |
| CG (R) | HP1, CDH1, PC, MPP8, CDY, CDYL, CDYL2, CBX7, MCL3, | H3K9me2/me3, H3K27me2/me3 | |
| Tudor (R) | PHF1, PHF19, PHF20, TDRD7, | H3K36me3 | |
| TTD (R) | 53BP1, KDM4A, KDM4B, KDM4C, Sgf29, UHRF1 | H3K4me3, H3K9me3, H4K20me2 | |
| MBT (R) | CGI-73, L(3)HBTL, SFMBT, PHF20L1 | H3K4me1, H3K9me1/me2, H3K20me1, H4K4me1 | |
| PWWP (R) | DNMT3A, BRPF1, NSD1-3, MSH-6, N-PAC, Pdp1 | H3K36me3, H4K20me1/me3, H3K79me3 | |
| ADD (Pt) | DNMT3L | H3K9me3 | |
| Ankyrin repeats | G9a/GLP | H3K9 me1/me2 | |
| BAH | ORC1 | H4K20me2 | |
| DCD (R) | CHD1 | H3K4me1/me2/me3 | |
| PHD (Pt) | BHC80, BPTF, AIRE, RAG2, ING1-5, BPTF, TAF3, PHF2, PNF8,PHF13, PHF13, Pygo, YNG1, SMCX, | H3K4me3, H3K4me2, H3K9me3 | |
| WD40 | WDR5/WDR9, EED, LRWD1, | H3K27me3, H3K9me3 | |
| zf-CW (Pt) | ZCWPW1 | H3K4me3 | |
| Methylarginine | ADD (Pt) | DNMT3L | H4R3me2 s |
| Tudor (R) | AKAPI1, TDRD2-3, TDRD5,TDRD8-10, SMN1, SPF30, | H3Rme2, H4Rme2 | |
| WD40 | WDR5 | H3R2me2 | |
| Acetyllysine | BD | GCN5, PRBM1, | H3Kac, H4Kac, H2AKac, H2BKac |
| DBD (R) | Rsc4, TAF1, Brdt, | H3KacKac, H4KacKac | |
| DFP (Pt) | DPF3b | H3K14ac | |
| PH | histone chaperone Rtt106 | H3K56ac | |
| Phosphoserine | 14-3-3 | 14-3-3ξ, 14-3-3β, 14-3-3γ, 14-3-3η, 14-3-3ε, 14-3-3μ, 14-3-3θ | H3S10ph, H3S28ph |
| tandem BRCT | H2A.XS139 (γH2AX) | ||
| Phosphothreonine | BIR | H3T3ph | |
| Propionyllysine | BD | Brd4 | H3K23 |
| Butyryllysine | BD | Brd4 | K3K14 |
| Unmodified H3 | ADD (Pt) | DNMT3L | unmodified histone H3 |
| PHD (Pt) | UHRF1 | unmodified histone H3 | |
| WD40 | Nurf55 | unmodified histone H3 |
ADD ATRX-DNMT3-DNMT3L, BAH bromo-adjacent homology, BD bromodomain, CD chromodomain, DCD double chromodomain, DBD double bromodomain, DFP double PHD finger, MBD methyl-CpG-binding domain, MBT malignant brain tumor, PH double pleckstrin homology, PHD plant homeodomain, PWWP Pro-Trp-Trp-Pro; SRA SET- and Ring finger-associated domain, TTD tandem Tudor domain, zf-CW zinc finger CW, (Pt) PHD-type, (R) Royal superfamily