Table 5.
miRNAs regulating epigenetic pathway-related genes
| MIRNA | Target | Role of target gene | Reference |
|---|---|---|---|
| DNA-modifying enzymes | |||
| miR-148 | DNMT1 | DNA methylation | Duursma et al. (2008) |
| miR-152 | DNMT1 | DNA methylation | Denis et al. (2011) |
| miR-301 | DNMT1 | DNA methylation | Iorio et al. (2010) |
| miR-126 | DNMT1 | DNA methylation | Denis et al. (2011) |
| miR148 | DNMT3B | DNA methylation | Denis et al. (2011) |
| mi-29 family | DNMT3A/3B | DNA methylation | Fabbri et al. (2007) |
| miR-132 | MeCP2 | Protect MeCp2 binding to DNA | Sato et al. (2011) |
| Transcription factors | |||
| miR-29b | Sp1 | Regulate DNMT1 transcription | Garzon et al. (2009) |
| miR-290 cluster | Rbl2 | Repressor of DNMTs transcription | Benetti et al. (2008), Sinkkonen et al. (2008) |
| miR-K12-4-5p virial | Rbl2 | Repressor of DNMTs transcription | Iorio et al. (2010), Lu et al. (2010) |
| Chromatin remodelers | |||
| miR-29b/c | YY1 | Recruits PCR2 and HDAC to specific genome locus | Sato et al. (2011) |
| miR-26a, miR-101, miR-205, miR-214, | EZH2 (belongs to PRC1 complex) | PCR1 catalyzes ubiquitination of histone H2A, cooperate with PRC2 | Sato et al. (2011) |
| miR-128, miR-203 | Bim1 (belongs to PRC2 complex) | PCR2 facilitates histone methylation | Sato et al. (2011) |
| Histone-modifying enzymes | |||
| miR-449a | HDAC1 | Histone deacetylation | Liep et al. (2012) |
| miR-1, miR-140 | HDAC4 | Histone deacetylation | Liep et al. (2012) |