Figure 7.

Modulation of Hog1 activation by pheromone and NaCl

1. A–J Specificity matrices of the following phosphopeptides: (A) Hog1_T174_Y176, (B) Ptp2_S258, (C) Ste50_S202, (D) Ste11_S323, (E) Ste20_T511, (F) Gpd1_S24_S27, (G) Pbs2_S68, (H) Ypk1_S644_S653, (I) Bit61_S139_S144, and (J) Nbp2_S196.
2. K–M Predicted mechanism for the cross-modulation of Hog1 double-phosphorylation by the co-stimulation with NaCl and pheromone. The connections that are known from already published studies are indicated in black; our predicted connections are in red.