Figure 1. A modular protein interaction network with modules containing enrichment of autism-associated genes.

Two topological modules (#2 and #13) on human protein interaction network showed significant enrichment for autism genes (in red). The topological modules are physical clusters on the network where their member genes intensively interact with each other but sparsely interact with non-member genes on the network. A zoom-in view of module #13 is also shown, where known autism genes and genes affected by ASD-associated de novo CNVs were colorized in red and green, respectively. Genes annotated by both were in blue. The false discovery rate indicates its significant enrichment for the known autism genes.