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. 2015 Jan 21;5:7916. doi: 10.1038/srep07916

Figure 7. Neomycin administration reduces HCC/HSC tumor growth by blocking angiogenin nuclear translocation and HCC development.

Figure 7

A, measurement of tumors from nude mice subcutaneously injected with HepG2/LX2 cells and treated intraperitonealy with saline or neomycin for eight weeks. B, Representative images of tumor cell proliferation by PCNA detection (40×), angiogenin levels (80×) and CD34 (40×) were visualized in tumor samples from mice treated with neomycin or saline. C, Quantification of PCNA positive cells in tumor slides. D, Quantification of CD34 positive areas in tumor slides. E, mRNA quantification of α-SMA and TGF-β in tumors, using β-actin as control. (n ≥ 6). *, p ≤ 0.05, neomycin vs. saline-injected animals. F, RNA quantification of RNA polymerase II (RPII) and 45S ribosomal RNA in tumors, as above.