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. 2014 Dec 17;15:438. doi: 10.1186/1471-2474-15-438

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© Lu et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Localization of HDAC4 in OA cartilage and normal cartilage. Aggrecan loss was much more severe in OA (B) than in normal cartilage (A). HDAC4 had significantly higher expression in OA (D,F) than in normal cartilage (C,E). A, B, C and D: 100x magnification (scale bar 100 μm); E,F: 200x magnification (scale bar 50 μm). Immunoreactive products are stained brown.