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. 2014 Dec 11;11:206. doi: 10.1186/s12974-014-0206-3

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© Jarius et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Double labeling of primate intestine sections with patient serum and with commercial antibodies to anti-ITPR1 or ARHGAP26, respectively. The anti-Sj index serum and the commercial antibody to ITPR1 (A) stained both the stratum circulare (SC) and the stratum longitudinale (SL) of the tunica muscularis as well as the muscularis mucosae (MM) and structures adjacent to the enteric villi (V), with a perfect overlay, but spared the plexus myentericus Auerbach (MP), which is located between SC and SL. Conversely, the anti-Ca index serum [30] and the commercial antibody to ARHGAP26 (B) both stained the MP (and the plexus submucosus Meissner; not shown) but spared the enteric muscle cells. Anti-ITPR1 or anti-ARHGAP26 reactivity is depicted in red (Alexa Fluor® 568), the patient antibody in green (Alexa Fluor® 488), and yellow indicates overlay of the two antibodies. Nuclei are shown in blue (DAPI).