FIG 2.

Comparison of JC virus NCCR organization in CSF and plasma of two PML patients. (A) For patient 2, the consensus NCCR sequence resembled the archetype (AR) sequence, while the minority viral variant shared by CSF and plasma/serum harbored a deletion of domain D and part of domain E. (B) For patient 3, the consensus NCCR sequence was rearranged but was identical in CSF and plasma and contained a duplicated DNA sequence that was absent in the minority viral variant. Numbers in parentheses indicate the original nucleotide sequence position in the archetype sequence.