TABLE 2.
Intracranial infection of 1-day-old newborn mice with SINV-eGFP and SINV/EILV chimerasa
| Virus | Dose (log10 PFU/animal) | Lethalityb |
|---|---|---|
| SINV-eGFP | 4.7 | 9/9 (100) |
| 4.3 | 6/9 (67) | |
| 3.3 | 5/9 (56) | |
| SINV-eGFP with EILV 3′ UTR | 4.8 | 1/7 (14) |
| 4.1 | 0/6 (0) | |
| 3.3 | 0/7 (0) | |
| SINV-eGFP with EILV structural ORF | 5.3 | 0/6 (0) |
| 4.6 | 0/6 (0) | |
| 3.8 | 0/7 (0) | |
| None (PBS control) | 0/7 (0) |
a
Mice were injected with ∼105 to 103 PFU/animal and were observed for clinical disease.
b
The number of mice that died or were sick and met euthanization criteria to the total number of infected mice. The values in parentheses are the percentages.