Table 2.

Sex-specific associations of plasma SAM, SAH, and their ratio with risk of colorectal adenoma, Tennessee Colorectal Polyp Study, 2003-2010

Analyte	Sex-Specific Analyte Level OR (95% CI)			p for trend	p for interactionc
	Tertile 1 (low)	Tertile 2	Tertile 3 (high)
MALES
SAM
Median, nM	63.2	86.0	119.9
Case/control	63/53	55/53	41/53
OR (95% CI) Modela	1.00 (ref)	0.75 (0.42-1.35)	0.59 (0.33-1.06)	0.08	0.04
OR (95% CI) Modelb	1.00 (ref)	0.53 (0.27-1.02)	0.38 (0.18-0.77)	0.007
SAH
Median, nM	19.7	27.5	36.6
Case/control	70/53	45/53	44/53
OR (95% CI) Modela	1.00 (ref)	0.59 (0.34-1.04)	0.53 (0.28-0.99)	0.04	0.02
OR (95% CI) Modelb	1.00 (ref)	0.54 (0.29-1.01)	0.45 (0.22-0.91)	0.02
SAM/SAH ratio
Median	2.5	3.2	4.4
Case/control	51/53	53/53	55/53
OR (95% CI) Modela	1.00 (ref)	1.05 (0.58-1.89)	1.11 (0.60-2.06)	0.75	0.48
OR (95% CI) Modelb	1.00 (ref)	1.16 (0.58-2.32)	1.06 (0.53-2.12)	0.89
FEMALES
SAM
Median, nM	65.5	84.5	96.8
Case/control	11/19	21/19	25/19
OR (95% CI) Modela	1.00 (ref)	2.65 (0.84-8.40)	2.79 (0.89-8.82)	0.10
OR (95% CI) Modelb	1.00 (ref)	2.24 (0.65-7.79)	2.38 (0.66-8.60)	0.20
SAH
Median, nM	15.5	20.2	29.2
Case/control	9/19	18/20	30/18
OR (95% CI) Modela	1.00 (ref)	3.16 (0.87-11.65)	3.99 (1.12-14.24)	0.04
OR (95% CI) Modelb	1.00 (ref)	3.45 (0.77-15.40)	5.18 (1.09-24.62)	0.04
SAM/SAH ratio
Median	3.2	3.9	4.9
Case/control	22/19	17/19	18/19
OR (95% CI) Modela	1.00 (ref)	0.80 (0.27-2.35)	1.07 (0.36-3.19)	0.86
OR (95% CI) Modelb	1.00 (ref)	0.74 (0.20-2.74)	1.00 (0.27-3.84)	0.92

^aAdjusted for age (years).

^bAdjusted for age (years), body mass index (kg/m²), cigarette smoking status (never, former, current), and income (0-$29,999, $30,000-$49,999, $50,000-$75,000, ≥ $75,000).

^cP for interaction comparing individual metabolite between males and females.