Table 3.
Influence of SNPs in 4 EGFR pathway genes on prognosis of HCC patients
| Gene | SNP | Log-rank p for OS | Log-rank p for DFS | ||||
|---|---|---|---|---|---|---|---|
|
| |||||||
| General | Dominant | Recessive | General | Dominant | Recessive | ||
| EGF | rs3756261 | 0.653 | 0.446 | 0.772 | 0.494 | 0.261 | 0.951 |
| EGF | rs11568835 | 0.966 | 0.865 | 0.87 | 0.852 | 0.914 | 0.571 |
| EGF | rs4444903 | 0.437 | - | - | 0.23 | - | - |
| EGF | rs11568943 | 0.621 | 0.636 | 0.496 | 0.512 | 0.372 | 0.652 |
| EGF | rs2237051 | 0.327 | 0.955 | 0.172 | 0.401 | 0.52 | 0.18 |
| EGF | rs11569017 | 0.713 | 0.716 | 0.537 | 0.699 | 0.493 | 0.759 |
| EGF | rs3733625 | 0.294 | 0.536 | 0.215 | 0.258 | 0.317 | 0.304 |
| EGFR | rs6965469 | 0.969 | 0.831 | 0.935 | 0.883 | 0.817 | 0.631 |
| EGFR | rs4947492 | 0.776 | 0.484 | 0.925 | 0.995 | 0.977 | 0.937 |
| EGFR | rs2227983 | 0.493 | 0.332 | 0.795 | 0.69 | 0.642 | 0.62 |
| EGFR | rs11977388 | 0.602 | 0.586 | 0.573 | 0.737 | 0.976 | 0.464 |
| EGFR | rs2293347 | 0.371 | 0.176 | 0.975 | 0.356 | 0.152 | 0.793 |
| EGFR | rs884225 | 0.435 | 0.631 | 0.198 | 0.345 | 0.611 | 0.793 |
| VEGF | rs699947 | 0.169 | 0.885 | 0.085 | 0.182 | 0.838 | 0.097 |
| VEGF | rs833061 | 0.277 | 0.622 | 0.109 | 0.296 | 0.736 | 0.123 |
| VEGF | rs2010963 | 0.373 | 0.989 | 0.19 | 0.274 | 0.728 | 0.174 |
| VEGF | rs1413711 | 0.231 | 0.716 | 0.09 | 0.251 | 0.794 | 0.103 |
| VEGF | rs833070 | 0.23 | 0.937 | 0.114 | 0.271 | 0.911 | 0.139 |
| VEGF | rs3025000 | 0.436 | 0.795 | 0.274 | 0.362 | 0.6 | 0.286 |
| VEGF | rs3025033 | 0.896 | 0.657 | 0.99 | 0.865 | 0.677 | 0.845 |
| VEGF | rs3025035 | 0.291 | 0.75 | 0.16 | 0.344 | 0.819 | 0.182 |
| VEGF | rs3025039 | 0.891 | 0.923 | 0.673 | 0.815 | 0.844 | 0.602 |
| VEGF | rs10434 | 0.267 | 0.206 | 0.55 | 0.452 | 0.382 | 0.538 |
| VEGFR2 | rs2071559 | 0.437 | 0.352 | 0.584 | 0.282 | 0.331 | 0.369 |
| VEGFR2 | rs7667298 | 0.33 | 0.245 | 0.607 | 0.214 | 0.236 | 0.386 |
| VEGFR2 | rs1531290 | 0.134 | 0.361 | 0.137 | 0.289 | 0.451 | 0.261 |
| VEGFR2 | rs6837735 | 0.788 | 0.51 | 0.994 | 0.679 | 0.406 | 0.972 |
| VEGFR2 | rs7692791 | 0.101 | 0.035 | 0.338 | 0.112 | 0.039 | 0.346 |
| VEGFR2 | rs2305948 | 0.038 | 0.025 | 0.132 | 0.163 | 0.078 | 0.331 |
| VEGFR2 | rs2034965 | 0.103 | 0.091 | 0.082 | 0.017 | 0.027 | 0.019 |
| VEGFR2 | rs1870377 | 0.113 | 0.34 | 0.163 | 0.141 | 0.134 | 0.498 |
| VEGFR2 | rs13109660 | 0.092 | 0.46 | 0.029 | 0.222 | 0.554 | 0.083 |
| VEGFR2 | rs6838752 | 0.028 | 0.263 | 0.066 | 0.063 | 0.123 | 0.272 |
| VEGFR2 | rs17709898 | 0.811 | 0.519 | 0.865 | 0.572 | 0.291 | 0.691 |
| VEGFR2 | rs1531289 | 0.384 | 0.341 | 0.219 | 0.118 | 0.164 | 0.066 |
| VEGFR2 | rs7691507 | 0.751 | 0.452 | 0.794 | 0.259 | 0.24 | 0.171 |
OS: Overall survival; DFS: Disease-free survival.