Table 4.
Toxicities caused by the two regimens
| Toxicity and grade | THP group | DOX group | P value |
|---|---|---|---|
|
| |||
| (n=47) | (n=49) | ||
| Hematological toxicities | |||
| Leucopenia | |||
| All | 42 (89.4%) | 46 (93.9%) | 0.334 |
| 3 | 12 (25.5%) | 16 (32.7%) | 0.294 |
| 4 | 5 (10.6%) | 7 (14.3%) | 0.410 |
| Anemia | |||
| All | 25 (53.2%) | 29 (59.2%) | 0.350 |
| 3 | 3 (6.4%) | 5 (10.2%) | 0.381 |
| Thrombocytopenia | |||
| All | 22 (46.8%) | 26 (53.1%) | 0.341 |
| 3 | 2 (4.2%) | 3 (6.1%) | 0.520 |
| Nausea and vomiting | |||
| All | 24 (51.1%) | 39 (79.6%) | 0.003 |
| 3-4 | 9 (19.1%) | 20 (40.8%) | 0.018 |
| Hepatic dysfunction | |||
| All | 24 (51.1%) | 27 (55.1%) | 0.424 |
| 3-4 | 9 (19.1%) | 10 (20.4%) | 0.541 |
| Renal dysfunction | |||
| 1-2 | 3 (6.4%) | 4 (8.2%) | 0.524 |
| Alopecia | |||
| 1-2 | 30 (63.8%) | 42 (85.7%) | 0.012 |
| Mucositis | |||
| All | 23 (48.9%) | 38 (75.6%) | 0.003 |
| 3-4 | 1 (2.1%) | 5 (10.2%) | 0.112 |
| Cardiac toxicities | |||
| Arrhythmia | |||
| 1-2 | 3 (6.4%) | 9 (18.4%) | 0.070 |
| Heart failure | |||
| 1-2 | 0 (0%) | 2 (4.1%) | 0.258 |
| Myocardial ischemia | |||
| 1-2 | 0 (0%) | 3 (6.1%) | 0.129 |
| Infection | |||
| 1-3 | 2 (4.2%) | 4 (8.2%) | 0.359 |
Categorical data are presented as numbers (percentages). Differences were analyzed by Fisher’s exact test or χ2 test according to the data distribution.