Table 2.
Comparison of clinical characteristics between BRCA mutation carriers and non-carriers
| Variable | Genetic Mutation | P-value | |
|---|---|---|---|
|
| |||
| No | Yes | ||
|
| |||
| N (%) | N (%) | ||
| Age at diagnosis (years) | 0.766 | ||
| ≤ 50 | 53 (75.7) | 13 (72.2) | |
| > 50 | 17 (24.3) | 5 (27.8) | |
| BMI (Kg/m2) | 0.002 | ||
| ≤ 30 | 49 (70.0) | 5 (27.8) | |
| > 30 | 21 (30.0) | 13 (72.2) | |
| Diagnosis | 1.000 | ||
| Ductal | 60 (85.7) | 16 (88.9) | |
| Lobular | 10 (14.3) | 2 (11.1) | |
| Stage | 1.000 | ||
| 1 and 2 | 55 (78.6) | 15 (83.3) | |
| 3 | 13 (18.6) | 3 (16.7) | |
| 4 | 2 (2.9) | 0 (0.0) | |
| Chemotherapy | 0.019 | ||
| No | 16 (23.5) | 0 (0.0) | |
| Yes | 52 (76.5) | 18 (100.0) | |
| Radiotherapy | 0.038 | ||
| No | 27 (38.6) | 12 (66.7) | |
| Yes | 43 (61.4) | 6 (33.3) | |
| Surgery | 0.431 | ||
| Lumpectomy | 36 (51.4) | 7 (38.9) | |
| Mastectomy | 34 (48.6) | 11 (61.1) | |
| ER positive | 0.120 | ||
| No | 28 (40.0) | 11 (61.1) | |
| Yes | 42 (60.0) | 7 (38.9) | |
| PR positive | 0.296 | ||
| No | 36 (51.4) | 12 (66.7) | |
| Yes | 34 (48.6) | 6 (33.3) | |
| HER2 positive | 0.018 | ||
| No | 52 (74.3) | 18 (100.0) | |
| Yes | 18 (25.7) | 0 (0.0) | |
| Triple negative | 0.014 | ||
| No | 50 (71.4) | 7 (38.9) | |
| Yes | 20 (28.6) | 11 (61.1) | |
| ER, PR positive & HER2 negative | 0.791 | ||
| No | 38 (54.3) | 11 (61.1) | |
| Yes | 32 (45.7) | 7 (38.9) | |
P-values were obtained using Fisher’s exact test.