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. 2014 Dec 15;5(1):114–124.

Figure 4.

Figure 4

LH regulated PHB, MMP-2 and MMP-9 protein expression through AKT and ERK1/2 signal pathway. The cells were treated with or without 50 mIU/ml LH for 48 h in serum-free cultures after pre-treatment with 10 μmol/L U0126 and LY294002 for 1 h, the protein expressions were investigated by western blot analysis. PBS treatment was used as a negative control. A. Shows ERK1/2 signaling inhibitor U0126 and AKT signaling inhibitor LY294002 block the up-regulation of prohibitin, MMP-2 and MMP-9 induced by LH in MCV152 cells. B. Shows ERK1/2 signaling inhibitor U0126 and AKT signaling inhibitor LY294002 block the up-regulation of prohibitin, MMP-2 and MMP-9 induced by LH in SKOV3 cells.