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. 2014 Dec 15;5(1):52–71.

Table 1.

Correlation among the expression levels of MCM family members in seven breast cancer patient cohorts; (A) GSE1456, (B) GSE2034, (C) GSE3141, (D) GSE3494, (E) GSE7390, (F) GSE11121, (G) GSE12276

A. GSE1456 dataset (n = 159) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .632** .734** .579** .403** .696**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .632** 1.000 .621** .588** .381** .682**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .734** .621** 1.000 .556** .378** .592**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .579** .588** .556** 1.000 .420** .586**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .403** .381** .378** .420** 1.000 .431**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .696** .682** .592** .586** .431** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
B. GSE2034 dataset (n = 286) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .622** .569** .615** .707** .653**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .622** 1.000 .431** .474** .591** .506**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .569** .431** 1.000 .432** .459** .536**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .615** .474** .432** 1.000 .592** .548**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .707** .591** .459** .592** 1.000 .459**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .653** .506** .536** .548** .459** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
C. GSE3141 dataset (n = 158) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .475** .352** .341** .487** .362**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .475** 1.000 .149 .353** .466** .361**
P value < 0.001 . 0.062 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .352** .149 1.000 .098 .466** .255**
P value < 0.001 0.062 . 0.222 < 0.001 0.001
MCM5 Correlation Coefficient .341** .353** .098 1.000 .317** .477**
P value < 0.001 < 0.001 0.222 . < 0.001 < 0.001
MCM6 Correlation Coefficient .487** .466** .466** .317** 1.000 .344**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .362** .361** .255** .477** .344** 1.000
P value. < 0.001 < 0.001 0.001 < 0.001 < 0.001 .
D. GSE3494 dataset (n = 236) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .688** .654** .690** .530** .659**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .688** 1.000 .515** .614** .493** .634**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .654** .515** 1.000 .526** .431** .533**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .690** .614** .526** 1.000 .444** .549**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .530** .493** .431** .444** 1.000 .407**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .659** .634** .533** .549** .407** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
E. GSE7390 dataset (n = 198) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .616** .578** .636** .664** .669**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .616** 1.000 .513** .605** .569** .682**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .578** .513** 1.000 .518** .540** .574**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .636** .605** .518** 1.000 .636** .673**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .664** .569** .540** .636** 1.000 .646**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .669** .682** .574** .673** .646** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
F. GSE11121 dataset (n = 200) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .710** .689** .624** .778** .629**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .710** 1.000 .571** .432** .666** .594**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .689** .571** 1.000 .508** .645** .539**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .624** .432** .508** 1.000 .650** .553**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .778** .666** .645** .650** 1.000 .558**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .629** .594** .539** .553** .558** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
G. GSE12276 dataset (n = 204) MCMs correlation
MCM2 MCM3 MCM4 MCM5 MCM6 MCM7
Spearman’s rho MCM2 Correlation Coefficient 1.000 .673** .554** .618** .698** .665**
P value . < 0.001 < 0.001 < 0.001 < 0.001 < 0.001
MCM3 Correlation Coefficient .673** 1.000 .605** .631** .688** .656**
P value < 0.001 . < 0.001 < 0.001 < 0.001 < 0.001
MCM4 Correlation Coefficient .554** .605** 1.000 .500** .535** .637**
P value < 0.001 < 0.001 . < 0.001 < 0.001 < 0.001
MCM5 Correlation Coefficient .618** .631** .500** 1.000 .724** .631**
P value < 0.001 < 0.001 < 0.001 . < 0.001 < 0.001
MCM6 Correlation Coefficient .698** .688** .535** .724** 1.000 .660**
P value < 0.001 < 0.001 < 0.001 < 0.001 . < 0.001
MCM7 Correlation Coefficient .665** .656** .637** .631** .660** 1.000
P value. < 0.001 < 0.001 < 0.001 < 0.001 < 0.001 .
**

Correlation is significant at the 0.01 level (2-tailed).