Table 3.
Correlation between the number of MCMs overexpressed and the prognosis for patients in seven breast cancer cohorts; (A) GSE1456, (B) GSE2034, (C) GSE3141, (D) GSE3494, (E) GSE7390, (F) GSE11121, (G) GSE12276
| A. Cox-regression analysis for GSE1456 (n = 159) | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 1.03 | 0.21-5.09 | 0.974 |
| 2 MCMs | 1.20 | 0.24-5.95 | 0.823 |
| 3 MCMs | 1.99 | 0.40-9.88 | 0.399 |
| 4 MCMs | 2.75 | 0.66-11.53 | 0.166 |
| 5 MCMs | 1.72 | 1.43-18.00 | 0.012 |
| 6 MCMs | 1.75 | 1.19-15.37 | 0.026 |
|
| |||
| B. Cox-regression analysis for GSE2034 (n = 286) | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 2.11 | 1.00-4.43 | 0.049 |
| 2 MCMs | 1.54 | 0.71-3.35 | 0.278 |
| 3 MCMs | 1.78 | 0.78-3.97 | 0.160 |
| 4 MCMs | 1.81 | 0.81-4.03 | 0.149 |
| 5 MCMs | 1.85 | 0.86-3.98 | 0.117 |
| 6 MCMs | 2.11 | 1.01-4.41 | 0.046 |
|
| |||
| C. Cox-regression analysis for GSE3141 (n = 158) | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 2.24 | 0.69-7.31 | 0.182 |
| 2 MCMs | 1.12 | 0.28-4.52 | 0.873 |
| 3 MCMs | 1.52 | 0.41-5.68 | 0.537 |
| 4 MCMs | 2.49 | 0.80-7.75 | 0.115 |
| 5 MCMs | 2.17 | 0.65-7.25 | 0.207 |
| 6 MCMs | 5.02 | 1.48-17.05 | 0.010 |
|
| |||
| D. Cox-regression analysis for GSE3494 (n = 236) | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 1.39 | 0.45-4.24 | 0.565 |
| 2 MCMs | 1.14 | 0.33-3.94 | 0.837 |
| 3 MCMs | 2.35 | 0.79-7.02 | 0.126 |
| 4 MCMs | 1.86 | 0.54-6.44 | 0.327 |
| 5 MCMs | 2.07 | 0.71-6.05 | 0.185 |
| 6 MCMs | 2.78 | 0.99-7.80 | 0.052 |
|
| |||
| E. Cox-regression analysis for GSE7390 (n = 198) | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 1.74 | 0.53-5.72 | 0.360 |
| 2 MCMs | 1.98 | 0.57-6.86 | 0.281 |
| 3 MCMs | 1.93 | 0.52-7.19 | 0.329 |
| 4 MCMs | 8.81 | 3.26-23.78 | < 0.001 |
| 5 MCMs | 4.39 | 1.52-12.67 | 0.006 |
| 6 MCMs | 1.43 | 0.45-4.52 | 0.539 |
|
| |||
| F. Cox-regression analysis for GSE11121 | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 1.25 | 0.77-2.03 | 0.364 |
| 2 MCMs | 1.29 | 0.76-2.20 | 0.346 |
| 3 MCMs | 2.07 | 1.21-3.54 | 0.008 |
| 4 MCMs | 2.65 | 1.57-4.46 | < 0.001 |
| 5 MCMs | 1.82 | 1.12-2.95 | 0.015 |
| 6 MCMs | 2.18 | 1.42-3.33 | < 0.001 |
|
| |||
| G. Cox-regression analysis for GSE12276 | |||
|
| |||
| Factor | Hazard Ratio | 95% CI | P value |
|
| |||
| MCMs overexpression | |||
| 0 MCM | Reference | ||
| 1 MCMs | 2.78 | 0.72-10.75 | 0.139 |
| 2 MCMs | 3.63 | 0.91-14.52 | 0.069 |
| 3 MCMs | 3.43 | 0.86-13.74 | 0.081 |
| 4 MCMs | 3.41 | 0.85-13.65 | 0.083 |
| 5 MCMs | 3.16 | 0.71-14.13 | 0.132 |
| 6 MCMs | 4.16 | 1.20-14.49 | 0.025 |