FIG 8.

The common parvovirus epitopes. (A and B) The AAV1 and CPV structures, respectively. The images are radially depth cued (colored from 110 to 130 Å) to visualize the capsid surface features, including the 5-fold channels, 3-fold protrusions, 2/5-fold wall, and 2-fold depressions. Panels C and E and panels D and F are capsid surface images and stereographic roadmap projections for AAV1 and CPV, respectively, showing the equivalent epitopes for the AAVs and CPV/FPV. In panels C and E, the epitope positions shared by three or four AAV serotypes are red and blue and those shared by two serotypes are pink and marine. In panels D and F, CPV/FPV epitopes identified by mutagenesis are red/blue (81) and those identified by cryo-reconstruction are red/blue and pink/marine (83).