TABLE 2.

Commonality in anti-AAV antibody epitopes^a

Amino acid	AAV1				AAV2		AAV5			AAV8 ADK8
	4E4	5H7	ADK1a	ADK1b	A20	C37B	3C5	ADK5a	ADK5b
458	N								T
493	K					S
494	T	T				A
495	D					D
496	N	N				N
497	N	N				N	R
498	N	N				N	A
499		S				S	V
500			N				S
588		S				S				N
589		T				R				T
254					N			N
256				L			Q	Q
258				K	K			R	R
259				Q				E
261				S	S			K
262					S			S
263				A				G
264				S	S
268							G	G
385				S	S			E
386				Q	Q			N
546							Q		Q
547				S			P	P	P
548							N	N	N
549					E		G	G	G
550							G	T	T
551								T	T
552								T	T
553								Y	Y
554								L	L
557					K			N	N
665							V	V
666							P	P
709				A	V		Q	Q	Q
710				N				F
716				D			D	D	D
717				N			S	S
718				N	N		T	T	T
719							G	G
720				L			E
721								Y	Y
722				T				R	R

^aEpitope residue numbers are based on AAV1 VP1; serotype-specific epitope residue types are shown.