FIG 6.

Prior VZV infection results in increased earlier but shorter duration memory T cell proliferation in the lungs following SVV challenge. The frequencies of proliferating central memory (CM) and effector memory (EM) CD4 and CD8 T cells in BAL samples (A to D) and PBMC (E to H) from RM 26244, RM 26362, and VZV-naive RMs were measured by flow cytometry based on the expression of Ki67. Results for VZV-naive RMs are the average values ± SEM. Statistical analysis was performed using two-way repeated-measures ANOVA with Bonferroni posttest to assess differences between VZV-immune RMs and VZV-naive RMs (P < 0.05: #, RM 26362; P < 0.01: **, RM 26244; ##, RM 26362; P < 0.001: ***, RM 26244; P < 0.0001: ####, RM 26362).