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Consensus motifs in the carboxy-terminal regions of diverse HPV E6 oncoproteins. Shown are the amino acid sequences of the C-terminal PDZ binding motifs (PBMs) of HPV-18, -16, -31, -33, -51, and -58, together with the HPV-31 E6 mutant derivatives delPDZ and T145AdelPDZ. At the top are shown the consensus recognition sequences for phosphorylation by PKA (36) and AKT (37). Also shown is the consensus PDZ binding motif.
