FIG 1.

Frameshift mutations in IHD-W strains. Whole-genome sequencing detected three different frameshift mutations not seen in the original IHD-W sequence (IHD-W0). Relative to strain DPP25, these insertions (*) created mutations within the A40R, D8L, and A56R genes. These insertions comprised an extra A added to an A₅ track in A40R (A), an extra dinucleotide (AT) added to an (AT)₃ repeat in D8L (sequencing also revealed a C-to-T mutation in the original IHD-W0 clone, indicated by #) (B), and an extra dinucleotide(AC) added to an (AC)₂ repeat in A56R (C).