TABLE 3.
Right TIR boundaries of vaccinia virusesh
| Strain | % retained gene contenta |
Genes comprising TIRs | |||
|---|---|---|---|---|---|
| DVX_211 (Cop B18) | DVX_212 (Cop B19) | DVX_213 | DVX_214-6b | ||
| Lister | 71 (N) | 0 | 0 | 0 | CPX-GRI 208,c CPX-GRI 209,c CPX-GRI 210-214 |
| DPP15 | 100 | 72 (N) | 0 | 0 | DVX_026-001 |
| TKT3 | 100 | 100 | 14 (N) | 15 (C) | DVX_013, DVX_012, DVX_009-001 |
| Cop | 100 | 100 | 16 (N) | 0 | DVX_011-001 |
| CVA | 100 | 100 | 28 (N) | 0 | DVX_019-006, DVX_002-001d |
| GLV-1h68 | 100 | 100 | 28 (N) | 0 | DVX_019-013, DVX_008, DVX_003-001e |
| DPP13 | 100 | 100 | 69 (N) | 28 (C) | DVX_013-001 |
| IHDW1 | 100 | 100 | 69 (N) | 28 (C) | DVX_013-001 |
| WR | 100 | 100 | 69 (N) | 28 (C) | DVX_013,f DVX_012,f DVX_018-014, DVX_006-001 |
| TP5 | 100 | 100 | 76 (N) | 0 | DVX_015-001 |
| TT12 | 100 | 100 | 76 (N) | 0 | DVX_015, DVX_014, DVX_010-001g |
| RPXV | 100 | 100 | 100 | 3 (N) | DVX_012-001 |
| DPP25 | 100 | 100 | 100 | 100 | DVX_013-001 |
N and C indicate that the value reported is the percentage of the gene's N or C terminus that is retained, respectively.
Resembles CPX-GRI B19R but is fragmented into three pieces (DVX_214-6) in DPP25. B19 belongs to the BTB/Kelch gene family.
The Lister homologs of CPX-GRI 208 and 209 are not located in TIR.
CVA encodes another 1.8-kbp deletion (DVX_003-005) in the TIRs.
GLV-1h68 encodes additional 2.6-kbp (DVX_009-012) and 1.7-kbp (DVX_004-007) deletions in the TIRs.
The WR homologs of DVX_013 and DVX_012 are not located within the TIR but are still present downstream of DVX_216.
TT12 encodes another 3-kbp deletion (DVX_011-013) in its TIRs.
Note that the conjunction site between DVX_216 and DVX_013 is still conserved in TKT3 virus, although TKT3 has a shorter TIR (only DVX_006 due to multiple deletions in the terminal regions).