Figure 6.

Collagen I, II, and X expression of micro mass cultures of mesenchymal stem cells (MSCs) and moderate and severely affected osteoarthritis (OA) chondrocytes. (a) Expression of Col I, Col II, and Col X of micro mass cultures of MSCs and chondrocytes from moderately affected OA tissue, grown with FGF2v1. (b) Ratio of Col II/Col I in micro mass cultures of MSCs or chondrocytes derived from moderate or severely OA tissue. Mean and standard deviation values are presented in each graph. Changes in relative expression were analyzed with a 2-tailed paired t test (21-24 patients) except when the pairing was not significantly effective, and then the 2-tailed Mann Whitney test was performed (marked with *). The statistical tests were performed as described in Materials and Methods, and significant P values are shown.