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. 2014 Dec 20;11:125. doi: 10.1186/s12977-014-0125-5

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© Qin et al.; licensee BioMed Central. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Illustration of structural elements on gp120 and eOD-GT6. (A) The crystal structure of SOSIP gp140 (accession code 4NCO) is used for the illustration. Gp120 is shown in grey, and regions corresponding to eOD-GT6 are shown in green. Amino acid residues identical between the MCON6 gp120 and eOD-GT6 are shown in yellow. (B and C) VRC01 contact residues are shown in red and V1/V2 and V3 loops are shown as a point of reference. PGT122 (an antibody related to PGT121 and PGT126) that was co-crystallized with SOSIP gp140 is shown with the critical N332 glycosylation site.