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. 2014 Dec 16;14:965. doi: 10.1186/1471-2407-14-965

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© Martinez-Useros et al.; licensee BioMed Central. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Irinotecan response is increased when DEK is silenced. Diagram shows percentage of apoptotic cells stained with Annexin-V after treatments. DLD1 and SW620 cell lines were DEK knocked-down and treated with SN38 or 5FU separately and compared with control cells (control siRNA and untreated). Combination of siDEK and SN38 increased apoptosis (P < 0.05) compared to control or DEK silenced in both cell lines. In addition, combination increased apoptosis (P < 0.05) compared to single SN38 treatment in DLD1 cell line. No significant differences were observed after 5FU treatment. Results are expressed as the average of downregulation with 2 different siRNA sequences (siDEKsec57 and 58) in triplicate.